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KMID : 1128320090070010001
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Electrolytes & Blood Pressure
2009 Volume.7 No. 1 p.1 ~ p.4
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Ubiquitination of Aquaporin-2 in the Kidney
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Lee Yu-Jung
KwonTae-Hwan
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Abstract
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Ubiquitination is known to be important for endocytosis and lysosomal degradation of aquaporin-2 (AQP2). Ubiquitin (Ub) is covalently attached to the lysine residue of the substrate proteins and activation and attachment of Ub to a target protein is mediated by the action of three enzymes (i.e., E1, E2, and E3). In particular, E3 Ub-protein ligases are known to have substrate specificity. This minireview will discuss the ubiquitination of AQP2 and identification of potential E3 Ub-protein ligases for 1-deamino-8-D-arginine vasopressin (dDAVP)-dependent AQP2 regulation.
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KEYWORD
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kidney tubules, collecting, ubiquitination, vasopressins, aquaporin 2
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